Paleo Meal Ideas . African hominin stable isotopic data do not necessarily indicate grass consumption. Proc Natl Acad Sci U S A. Sep 2. 3. Metabolic effects of milk protein intake strongly depend on pre- existing metabolic and exercise status. Nutr Metab (Lond). Download PDFAbstract: Milk protein intake has recently been suggested to improve metabolic health. This Perspective provides evidence that metabolic effects of milk protein intake have to be regarded in the context of the individual’s pre- existing metabolic and exercise status. Milk proteins provide abundant branched- chain amino acids (BCAAs) and glutamine. Plasma BCAAs and glutamine are increased in obesity and insulin resistance, but decrease after gastric bypass surgery resulting in weight loss and improved insulin sensitivity. Milk protein consumption results in postprandial hyperinsulinemia in obese subjects, increases body weight of overweight adolescents and may thus deteriorate pre- existing metabolic disturbances of obese, insulin resistant individuals. The impact of cow’s milk- mediated m. TORC1- signaling in the initiation and progression of prostate cancer.
Nutr Metab (Lond). Aug 1. 4; 9(1): 7. Download PDFAbstract: Prostate cancer (PCa) is dependent on androgen receptor signaling and aberrations of the PI3. K- Akt- m. TORC1 pathway mediating excessive and sustained growth signaling. The nutrient- sensitive kinase m. TORC1 is upregulated in nearly 1. PCas. Oncogenic m. TORC1 signaling activates key subsets of m. RNAs that cooperate in distinct steps of PCa initiation and progression. Epidemiological evidence points to increased dairy protein consumption as a major dietary risk factor for the development of PCa. This review provides evidence that PCa initiation and progression are promoted by cow. Mammalian milk is presented as an endocrine signaling system, which activates m. TORC1, promotes cell growth and proliferation and suppresses autophagy. Naturally, milk- mediated m. TORC1 signaling is restricted only to the postnatal growth phase of mammals. However, persistent consumption of cow. BCAAs, insulin and IGF- 1 are pivotal activating signals of m. TORC1. Increased cow. As well- balanced m. TORC1- signaling plays an important role in appropriate prostate morphogenesis and differentiation, exaggerated m. TORC1- signaling by high cow. Attenuation of m. TORC1 signaling by contemporary Paleolithic diets and restriction of dairy protein intake, especially during m. TORC1- dependent phases of prostate development and differentiation, may offer protection from the most common dairy- promoted cancer in men of Western societies. Malaria and rickets represent selective forces for the convergent evolution of adult lactase persistence. In: Biodiversity in Agriculture: Domestication, Evolution and Sustainability, Gepts P, Famula T, Bettinger R et al. Exercise Like a Hunter Gatherer: A Prescription for Organic Physical Fitness. Progress in Cardiovascular Disease, 2. Abstract: A large proportion of the health woes beleaguering modern cultures are because of daily physical activity patterns that are profoundly different from those for which we are genetically adapted. The ancestral natural environment in which our current genome was forged via natural selection called for a large amount of daily energy expenditure on a variety of physical movements. Our genes that were selected for in this arduous and demanding natural milieu enabled our ancestors to survive and thrive, leading to a very vigorous lifestyle. Dr Jayaprakash, the Ayurvedic healer and Managing Director of Dharma Ayurveda in Trivandrum, India, believes that This abrupt (by evolutionary time frames) change from a very physically demanding lifestyle in natural outdoor settings to an inactive indoor lifestyle is at the origin of many of the widespread chronic diseases that are endemic in our modern society. The logical answer is to replicate the native human activity pattern to the extent that this is achievable and practical. Recommendations for exercise mode, duration, intensity, and frequency are outlined with a focus on simulating the routine physical activities of our ancient hunter- gatherer ancestors whose genome we still largely share today. In a typical inactive person, this type of daily physical activity will optimize gene expression and help to confer the robust health that was enjoyed by hunter- gatherers in the wild. The western diet and lifestyle and diseases of civilization. Res Rep Clin Cardiol 2. Abstract: It is increasingly recognized that certain fundamental changes in diet and lifestyle that occurred after the Neolithic Revolution, and especially after the Industrial Revolution and the Modern Age, are too recent, on an evolutionary time scale, for the human genome to have completely adapted. This mismatch between our ancient physiology and the western diet and lifestyle underlies many so- called diseases of civilization, including coronary heart disease, obesity, hypertension, type 2 diabetes, epithelial cell cancers, autoimmune disease, and osteoporosis, which are rare or virtually absent in hunter- gatherers and other non- westernized populations. It is therefore proposed that the adoption of diet and lifestyle that mimic the beneficial characteristics of the preagricultural environment is an effective strategy to reduce the risk of chronic degenerative diseases. Download PDF. The Paleolithic Athlete: The Original Cross Trainer. In: Anthropology of Sport and Human Movement, Sands R. Download PDFO’Keefe JH, Vogel R, Lavie CJ, Cordain L. Organic Fitness: Physical Activity Patterns Compatible with our Hunter Gatherer Genetic Legacy. Physician and Sports Medicine 2. Abstract: Many of the pervasive health concerns in modern society are the result of diet and lifestyle choices that are at odds with the evolutionary milieu for which we remain genetically adapted. This systematic displacement from a very physically active lifestyle in a natural outdoor environment to a sedentary indoor lifestyle may be at the root of many chronic diseases that are endemic in our culture. Cholesterol! It’s the evil substance plugging arteries everywhere, and statins are the drug industry’s Drano. Even orange juice is jumping on the bandwagon! February 2014 Issue. Nutrition, Inflammation, and Disease By Mary Franz, MS, RDN, LDN Today’s Dietitian Vol. Suggested CDR Learning Codes: 2060. Cocoa extract is a bitter mixture with a chocolate taste, made up of xanthine molecules (theobromine and caffeine) and procyanidins. Supplementing cocoa extract may. There is an evolving debate about the value of assessing levels of C-reactive protein (CRP) and other soluble biomarkers of inflammation for the prediction of first. A proposed solution is to simulate indigenous human activity patterns in such a way that is possible and practical for individuals to achieve. Suggestions for exercise mode, duration, intensity, and frequency are outlined, with a focus on realigning our daily physical activities with the archetype that is encoded within our genome. In a sedentary individual, this type of daily physical activity should help confer the robust vigorous health that enabled our ancestors to survive and thrive as hunter- gatherers in the wild. Download PDFKuipers RS, Luxwolda MF, Janneke Dijck- Brouwer DA, Eaton SB, Crawford MA, Cordain L, Muskiet FA. Estimated macronutrient and fatty acid intakes from an East African Paleolithic diet. Brit J Nutr , 2. 01. Dec; 1. 04(1. 1): 1. Abstract: The systematic displacement from a very physically active lifestyle in our natural outdoor environment to a sedentary, indoor lifestyle is at the root of many of the ubiquitous chronic diseases that are endemic in our culture. The intuitive solution is to simulate the indigenous human activity pattern to the extent that this is possible and practically achievable. Suggestions for exercise mode, duration, intensity, and frequency are outlined with a focus on realigning our daily physical activities with the archetype that is encoded within our genome. Download PDFEaton SB, Konner MJ, Cordain L. Diet- dependent acid load, Paleolithic nutrition, and evolutionary health promotion. Am J Clin Nutr 2. Download PDF. Paleolithic nutrition: what did our ancestors eat? In: ISS 2. 00. 9 Genes to Galaxies. Eds: Selinger A, Green A. The Science Foundation for Physics, University of Sydney. University Publishing Service, University of Sydney, Sydney, 2. Download PDFRamsden CE, Faurot KR, Carrera- Bastos P, Sperling LS, de Lorgeril M, Cordain L. Dietary fat quality and coronary heart disease prevention: a unified theory based on evolutionary, historical, global and modern perspectives. Curr Treat Options Cardiovasc Med; 2. Abstract: A large and growing body of evidence indicates that dietary fatty acids regulate crucial metabolic processes involved in the pathogenesis of coronary heart disease (CHD). Despite this evidence, optimal dietary fatty acid intakes for CHD prevention remain unclear. Significant gaps in the modern nutrition literature and contradictions in its interpretation have precluded broad consensus. These shortcomings can be addressed through the incorporation of evolutionary, historical, and global perspectives. The objective of this review is to propose a unified theory of optimal dietary fatty acid intake for CHD prevention that integrates critical insights from evolutionary, historical, global, and modern perspectives. This broad approach may be more likely than previous methods to characterize optimal fatty acid intakes. Download PDFEaton SB, Cordain L, Sparling PB, Cantwell JD. Evolution, body composition and insulin resistance. Preventive Medicine, 2. Abstract: Objective. Better understanding of the relationships between body composition and insulin resistance. Results. Average human adiposity and sarcopenia have attained unprecedented levels and the resultantly abnormal body composition distorts insulin receptor balance. Compared to evolutionary norms we now have too many adipocyte insulin receptors (in adipose tissue and liver) and too few myocyte insulin receptors. The body’s insulin receptors can be conceptualized as competing for insulin molecules released from the pancreas. When an insulin molecule docks on an adipocyte receptor, substantially fewer glucose molecules are cleared from the blood than when an insulin molecule docks on a myocyte insulin receptor. Populational insulin receptor imbalance would seem to parallel the secular rise in insulin resistance and offers an attractive pathophysiological explanation for the accompanying type 2 diabetes epidemic.
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